Nonparallel nephrotoxicity dose-response curves of aminoglycosides
نویسندگان
چکیده
منابع مشابه
Aminoglycosides: nephrotoxicity.
Aminoglycosides have long been one of the commonest causes of drug-induced nephrotoxicity (137). Although a clear recognition of the patientand treatment-related risk factors (91), combined with the once-a-day schedule and effective monitoring procedures (98), have definitely improved the situation over what prevailed in the early 1980s (115), we are still short of having brought the safety of ...
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We develop tools from computational algebraic geometry for the study of steady state features of autonomous polynomial dynamical systems via elimination of variables. In particular, we obtain nontrivial bounds for the steady state concentration of a given species in biochemical reaction networks with mass-action kinetics. This species is understood as the output of the network and we thus bound...
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To the Editor:—The critique by Eger et al. on the article by Eckenhoff and Johansson concerns combining the dose–response curves of several ion channels to make them steeper. The slopes of the in vivo studies are steep, whereas those of the in vitro studies are gradual. Both groups anticipate that when several binding sites among ion channels are combined, the dose–response curves may become st...
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Backgound: The major obstacle limiting the use of aminoglycoside, antibiotics has been and continues to be the possibility of drug induced ototoxicity and nephrotoxicity. Study dsign: Changes in biochemical parameters related to nephropathy before and after of nigella sativa were observed. Material and methods: Ten rabbits were included in the study, comprised as group 1 and 11. Group I was onl...
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A possible experimental design for combination experiments is to compare the dose-response curve of a single agent with the corresponding curve of the same agent using either a fixed amount of a second one or a fixed dose ratio. No interaction is then often defined by a parallel shift of these curves. We have performed a systematic study for various types of dose-response relations both for the...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1981
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.19.6.1024